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← ConditionsWomen's hormonal & reproductive

PMOS

Insulin-resistance & hyperandrogenism driven; ovulation is downstream, so metabolic correction leads.

Decision support, not prescription. You decide.

Primary: Metabolic & Weight ManagementSecondary: Muscle, Performance & Body CompositionSecondary: Immune & Inflammation ModulationSummary grade: strong
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Warning — Topical peptide/growth-factor serums worsen hirsutism

Speed hair growth and cannot distinguish skin from hair — avoid topical peptide serums on the face in PCOS/hirsutism.

Candidate agents

4 agents · ranked by role, then evidence
Semaglutidepeptide · headlineLeadResearch use only
Evidence · PubMed
Strong

GLP-1 RAs reduce weight & testosterone in PCOS; ovulation benefit downstream of weight loss.

PMID 32442310
Community · Reddit
No community reports
Peers · your network
No peer data yet
Kisspeptin-10peptide · headlineResearch use only
Evidence · PubMed
Emerging

Kisspeptin rescued ovulation in only 2/12 women (pilot) — lean-PCOS only, not clinically ready.

PMID 31820802
Community · Reddit
No community reports
Peers · your network
No peer data yet
Tirzepatidepeptide · headlineResearch use only
Evidence · PubMed
No evidence rows
Community · Reddit
Positive

20 reports · Cycle regularized quickly, weight loss, less brain fog/inflammation, fertility restored

Peers · your network
No peer data yet
Metforminoff-label Rx · medium oversightFDA-approved
Evidence · PubMed
Strong

Insulin sensitizer (AMPK); improves insulin resistance, hyperandrogenism/hirsutism and menstrual regularity — long-standing first-line metabolic agent in PCOS per international evidence-based guidelines.

PMID 38163998
Community · Reddit
No community reports
Peers · your network
No peer data yet

Matching protocol templates

Browse all →
Exenatide + Semaglutide Transition Strategy

Staggered hunger control, cost reduction, side effect modulation

6–12 weeks·2 components
Kisspeptin-10 + HCG + Clomid Testosterone Restoration Stack

Natural testosterone restoration, fertility support, HPTA recovery

6–12 weeks·3 components
Kisspeptin-10 + PT-141 + Cialis Libido Optimization Stack

Libido enhancement and erectile support

4–6 weeks (on demand)·3 components

The platform surfaces evidence, community signal and peer outcomes with enforced cautions. It never decides treatment — the licensed clinician orders labs, writes notes, and prescribes.