Kisspeptin-10

Kisspeptin-10 is a potent regulator of reproductive hormone signaling that stimulates GnRH secretion from the hypothalamus, which in turn increases LH and FSH levels to support testosterone, estrogen, and fertility. It has been studied for its role in treating hypogonadism, improving libido, and optimizing reproductive cycles. Emerging research also suggests metabolic benefits through its effects on insulin sensitivity and fat regulation.

• Activates KISS1 receptors in the hypothalamus, stimulating GnRH release and increasing LH (Luteinizing Hormone) & FSH (Follicle-Stimulating Hormone) secretion.
• Enhances gonadal steroid production, leading to increased testosterone and estrogen levels.
• May improve metabolic health, influencing leptin, insulin signaling, and adipocyte function.

• unit: mcg

  low dose: 1

  frequency: Single dose or daily for 2–4 weeks (research setting)

  high dose: 10

  standard dose: 4

  administration route: Subcutaneous (SQ)

• Inject 0.4 mcg/kg SubQ daily for 2–4 weeks, followed by reevaluation of hormonal markers. Cycle every 6–12 weeks depending on reproductive goals. Monitor for changes in LH, FSH, testosterone, or estrogen levels.

common: ["Transient flushing (warmth and redness, face)","Mild headache, nausea, lightheadedness"]

warnings: ["Only short-term dosing studied in humans"]

sequence: YNWNSFGLRF-NH2

half life: Around 30 minutes in plasma.

degradation: Rapidly degraded enzymatically in plasma.

molecular weight: 1302.4

molecular formula: C63H83N17O14

tissue specificity: Primarily affects the hypothalamic-pituitary-gonadal axis.

• The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans.reviewPMID 34962670 ↗
• Kisspeptin-10 stimulates release of LH and testosterone in male goats.preclinicalPMID 22694333 ↗