🧠Neuroprotective & Cognitive Enhancers
13 peptides in this category
Cortexin
Cortexin is a peptide-based neurobioregulator derived from bovine brain extracts, widely used in Eastern Europe for cognitive decline, stroke recovery, and neurodevelopmental disorders. It exerts neuroprotective, metabolic, and anti-inflammatory effects, enhancing memory, learning, and synaptic repair.
Standard dose: 10 mg IM daily for 10 days; repeat cycle every 3–6 months as needed.
Cortagen
Cortagen is a short synthetic tetrapeptide that exhibits neuroprotective and regenerative effects, particularly after injury. It has been shown to support cognitive function, nerve regrowth, and cardiovascular recovery. Used in protocols for TBI, aging, ischemia, and inflammatory neurodegeneration.
0.1 mg/kg SubQ once daily for 10–20 days per cycle. Repeatable 2–4x yearly depending on goal.
DSIP (Delta Sleep-Inducing Peptide)
DSIP (Delta Sleep-Inducing Peptide) is a short neuropeptide with documented ability to promote deep sleep, reduce stress, and modulate circadian rhythms. Often used to support recovery, anxiety reduction, and HPA balance, DSIP has broad experimental interest for its neuroendocrine effects.
200 mcg SubQ 30–60 minutes before sleep. Use for 2–4 weeks per cycle.
Dihexa
Dihexa is a synthetic neurogenic peptide that enhances cognitive performance and brain plasticity through HGF/c-Met activation. It promotes memory formation, synaptic repair, and long-term potentiation, and is under investigation for Alzheimer's, stroke recovery, and neurodegeneration.
5 mg oral daily or 1% topical cream applied 1–2x daily for 8–12 weeks.
FGL
FGL (FG loop peptide) is a synthetic neuropeptide derived from NCAM sequences that promotes neural repair, neurotrophin signaling, and memory formation. It enhances learning via FGFR1 activation and is under investigation for cognitive impairment, Alzheimer’s, and ischemia recovery. Delivered intranasally, it bypasses the BBB and targets brain-specific pathways.
400 mcg intranasally 3–5x per week. Suggested cycle duration: 6–12 weeks.
Orexin A
Orexin A is a wake-promoting neuropeptide that modulates sleep, alertness, appetite, and cognitive function. It acts on orexin receptors in the brain and is being researched as a treatment for narcolepsy, fatigue, and age-related cognitive decline. Intranasal delivery allows fast CNS uptake for energizing and neurostimulant effects.
2.5 mg intranasally once daily in the morning or as needed. Adjust based on arousal and tolerance.
PACAP
PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a neuroprotective peptide with potent effects on neuron survival, cognition, and inflammation regulation. It has shown promise in models of Alzheimer’s, stroke, and cognitive decline, while also being studied for its role in migraine physiology.
200 mcg intranasal 3–5x/week for up to 12 weeks. Adjust based on cognitive, migraine, or neuroprotective outcomes.
P21
P21 is an investigational tumor-targeting peptide under preclinical development for oncology and neurotherapeutics. It acts by penetrating cancer cells via CXCR4 or similar receptors and may disrupt mitochondrial energy production. It is also being evaluated for cell-penetrant cargo delivery and cognitive enhancement.
No standard clinical dose established. Protocols vary across preclinical and investigational uses.
Oxytocin
Oxytocin is a nonapeptide hormone that promotes uterine contraction, lactation, and emotional bonding. Intranasal oxytocin is under investigation for its effects on social cognition, emotional regulation, and conditions like autism and anxiety. It modulates brain circuits related to trust, fear, and empathy.
Typical intranasal doses range from 24–48 IU daily in divided applications for behavioral studies. Dose depends on condition and clinical context.
N-Acetyl Selank Amidate
N-Acetyl Selank Amidate is a nootropic peptide derived from tuftsin and enhanced through N-acetylation for improved stability. It modulates GABA, serotonin, and neurotrophic signaling and has demonstrated powerful anti-anxiety, cognitive-enhancing, and immunomodulatory effects in preclinical and clinical settings. Its intranasal use enables fast CNS action with a high safety margin. It has been investigated in Russian research for immune modulation and neurochemical balance.
Typical dose: 300 mcg intranasally 1–3x daily for 10–14 days per cycle.
Pinealon
Pinealon is a synthetic tripeptide bioregulator derived from pineal and brain tissue that promotes neuroprotection, memory consolidation, and pineal gland function. It is used in aging, cognitive decline, and circadian rhythm regulation protocols and has demonstrated antioxidant and geroprotective properties in preclinical studies.
5 mcg/kg SubQ daily for 10–20 days per cycle. Repeat 2–3x annually for aging support.
Semax
Semax is a synthetic ACTH-derived neuropeptide used for its cognitive-enhancing, neuroprotective, and antidepressant effects. Developed in Russia, it modulates neurotransmitters and neurotrophic factors like BDNF. It is used in cognitive decline, stress recovery, stroke rehabilitation, and neuropsychiatric disorders in both animal models and limited human trials.
0.1 mg intranasally 2–3 times daily for 10–14 days per cycle. Repeatable as needed with breaks.
Adamax
Adamax is a next-generation nootropic peptide and enhanced Semax analog featuring N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration. It upregulates BDNF, enhances TrkB receptor sensitivity, modulates monoamines, and provides neuroprotection against oxidative stress and excitotoxicity.
Standard dose: 300-1000 mcg daily via intranasal spray or injection, administered daily with gradual titration.