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Pinealon

Neuroprotective & Cognitive Enhancers

Pinealon is a synthetic tripeptide bioregulator derived from pineal and brain tissue that promotes neuroprotection, memory consolidation, and pineal gland function. It is used in aging, cognitive decline, and circadian rhythm regulation protocols and has demonstrated antioxidant and geroprotective properties in preclinical studies.

Reconstitute
3 mL BAC + 10mg vial
33 mcg/unit
Daily Range
3–10 mcg Subcutaneous (SQ)
Daily
Standard Dose
5 mcg
Cycle
4–8 weeks
then reassess
Pinealonpineal peptidenootropiccognitive enhancementcircadian rhythm

Dosing & Reconstitution Guide

In animal studies, Pinealon is typically used at doses of 100–300 μg/kg via injection. Clinical equivalents are unvalidated.

Standard / Gradual Approach

20mg Vialstandard
PhaseDoseVolume
Weeks 1–2200 mcg (0.20 mg)3 units (0.03 mL)
Weeks 3–4300 mcg (0.30 mg)4.5 units (0.045 mL)
Weeks 5–6400 mcg (0.40 mg)6 units (0.06 mL)
Weeks 7–12500 mcg (0.50 mg)7.5 units (0.075 mL)

Protocol Summary

Subcutaneous (SQ): Daily · Dose range 3–10 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

SubQ Injection

Administer daily for 10–20 days. Repeat every 4–6 months for cognitive maintenance or aging support.

🧪 Quick Start

Vial Size
10 mg
BAC Water
3 mL
Concentration
3300 mcg/unit
Starting Dose
200 mcg (0.20 mg) (3 units (0.03 mL))
Maintenance Dose
500 mcg (0.50 mg) (7.5 units (0.075 mL))

Potential Benefits & Use Cases

Pinealon is a research peptide not approved for human or therapeutic use. All information reflects experimental findings.
Demonstrates neuroprotective and anti-oxidative effects in brain tissue models (preclinical)
Modulates epigenetic markers and preserves neuronal structures (spines and synapses) (preclinical)
Improves working memory in 59.4% of subjects in clinical study (limited human data)
Shows benefit in traumatic brain injury recovery — improved memory and cognitive performance in 72 TBI patients (limited human data)
Suppresses ROS accumulation and activates antioxidant enzyme synthesis in cerebellar neurons (preclinical)
Clinical data Strong preclinical Limited data

Mechanism of Action

→Crosses the blood-brain barrier and enhances neural gene expression
→Supports pineal gland-mediated hormonal balance (e.g., melatonin)
→Increases resistance of neurons to oxidative stress and metabolic damage
→Stabilizes bioelectrical activity in cerebral cortex and hippocampus

Stacking Synergies

+
N-Acetyl Epithalon Amidate
Enhances neurogenic regeneration with Epitalon
+
Semax
Synergizes with Semax for cognitive performance and BDNF upregulation
+
PE-22-28
Boosts neuroprotective outcomes with cerebroprotective agents

Lifestyle & Optimization

diet

Maintain consistent nutrition. Minimize caffeine and alcohol.

sleep

Track outcomes with validated cognitive tools.

timing

Standardize sleep-wake windows. Evening dosing may support melatonin production.

exercise

Moderate activity.

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
MDPI International Journal of Molecular Sciences — Peptide Regulation of Gene Expression: A Systematic ReviewReference
PubMed — Peptide bioregulators: geroprotective agentsReference
PubMed Central — Short Peptides: Fundamental and Applied AspectsReference
MDPI Molecules — Molecular Mechanisms of Peptide BioregulatorsReference
Bulletin of Experimental Biology and Medicine — Pinealon effect on cell cultures during oxidative stressReference

Side Effects & Safety

Common Side Effects

• Headaches (tension-like)
• Vivid dreams/insomnia if taken late
• Mild anxiety, dizziness, nausea
• Changes in bowel habits

🧮 Dose Calculator

Concentration
33.3
mcg/unit
Draw Volume
15
units (0.150 mL)
For a 500 mcg dose, draw 15 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
High systemic bioavailability with direct delivery to central circulation
Oral Administration
Low; degraded in GI tract unless encapsulated or nano-formulated
Half-Life
Approximately 20 minutes
Degradation
Metabolized by tissue peptidases and liver enzymes
Tissue Specificity
Targets pineal gland, hippocampus, and neocortex
⚗️

Peptide Details

Molecular Weight
200.25
Formula
C10H16N2O3
Sequence
Lys-Gly-Asn
⚖️

Legal Status & Regulatory

RegionStatus
EUNot Approved
FDANot Approved
CanadaNot Approved
AustraliaNot Approved

Storage Instructions

Lyophilized (Powder)
store at −20 °C (−4 °F) protected from light; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); minimize freeze–thaw cycles
Reconstituted (Mixed)
Refrigerate at 2–8 °C (35.6–46.4 °F); aliquot if needed and avoid freeze–thaw