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N-Acetyl Selank Amidate

Neuroprotective & Cognitive Enhancers

N-Acetyl Selank Amidate is a nootropic peptide derived from tuftsin and enhanced through N-acetylation for improved stability. It modulates GABA, serotonin, and neurotrophic signaling and has demonstrated powerful anti-anxiety, cognitive-enhancing, and immunomodulatory effects in preclinical and clinical settings. Its intranasal use enables fast CNS action with a high safety margin. It has been investigated in Russian research for immune modulation and neurochemical balance.

Reconstitute
3 mL BAC + 10mg vial
33 mcg/unit
Daily Range
200–500 mcg Intranasal
1–3x daily
Standard Dose
300 mcg
Cycle
4–8 weeks
then reassess
SelankN-Acetyl Selank Amidateanxiolytic peptidecognitive enhancertuftsin analog

Dosing & Reconstitution Guide

Doses ranging from 250–500 μg intranasally have been used in regional clinical trials. This information is presented for research context only.

Standard / Gradual Approach

10mg Vialstandard
PhaseDoseVolume
Weeks 1–2300 µg (0.3 mg)9 units (0.09 mL)
Weeks 3–4500 µg (0.5 mg)15 units (0.15 mL)
Weeks 5–6750 µg (0.75 mg)23 units (0.23 mL)
Weeks 7–81000 µg (1.0 mg)30 units (0.30 mL)

Standard / Gradual Approach

5mg Vialstandard
PhaseDoseVolume
Weeks 1–2300 mcg18 units (0.18 mL)
Weeks 3–4500 mcg30 units (0.30 mL)

Standard / Gradual Approach

10mg Vialstandard
PhaseDoseVolume
Weeks 1–2300 mcg (0.3 mg)9 units (0.09 mL)
Weeks 3–4500 mcg (0.5 mg)15 units (0.15 mL)

Protocol Summary

Intranasal: 1–3x daily · Dose range 200–500 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

Intranasal

Use 1–3x per day for 10–14 days. Repeat cycles monthly as needed for mood, anxiety, or performance support.

🧪 Quick Start

Vial Size
10 mg
BAC Water
3 mL
Concentration
3300 mcg/unit
Starting Dose
300 µg (0.3 mg) (9 units (0.09 mL))
Maintenance Dose
1000 µg (1.0 mg) (30 units (0.30 mL))

Potential Benefits & Use Cases

Selank and its analogs are not approved in the U.S. and are intended for research purposes only.
Enhances cognitive function: improves learning, memory consolidation, and mental clarity (extrapolated from Selank human data)
Supports neuronal survival and recovery in ischemic and oxidative stress models (preclinical)
Modulates dopamine and serotonin systems, potentially improving stress resilience (preclinical)
Increases BDNF levels, promoting synaptic growth and neural connectivity (preclinical)
Parent compound Selank shows efficacy comparable to benzodiazepines for generalized anxiety disorder without sedation or tolerance (human trial — Selank)
Clinical data Strong preclinical Limited data

Mechanism of Action

→Modulates GABAergic neurotransmission via gene expression and receptor sensitivity
→Influences serotonin and dopamine balance through neuropeptide regulation
→Upregulates BDNF expression and neuroplasticity markers
→Reduces pro-inflammatory cytokines in brain and periphery
→Enhances adaptive stress response and immune homeostasis

Stacking Synergies

+
Semax
Combines with Semax to enhance cognitive performance and anxiolysis
+
PACAP
Boosts mood regulation and neuronal resilience with PACAP
+
Cortexin
Can be cycled with Cortexin for immune and neurovascular support

Lifestyle & Optimization

diet

Omega-3s, antioxidants, and B vitamins for brain health.

sleep

Consistent sleep (7–9 hours). Stress management (meditation, breathwork).

timing

Intranasal 1–3x daily. Can be used throughout the day.

exercise

Regular aerobic and resistance exercise.

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
PubMed — Semax: structure, mechanism, and therapeutic potential (ACTH analog overview)Reference
PMC (NCBI) — ACTH(4–10) analogs: neuroprotective and cognitive effectsReference
Medicinal Chemistry Letters — Adamantane modifications enhance peptide stability and CNS penetrationReference
Journal of Neurochemistry (2006) — Semax binds specific brain sites and increases BDNF protein in rat basal forebrainReference
Neuroscience and Behavioral Physiology — BDNF and TrkB receptor modulation by ACTH analogs (neuroplasticity mechanisms)Reference
PubMed — Semax effects on dopamine and serotonin neurotransmission (mood and cognition)Reference
Bulletin of Experimental Biology and Medicine — Semax improves learning and memory in animal modelsReference
PubMed — Neuroprotective effects of Semax in cerebral ischemia modelsReference
PubMed — Clinical safety and tolerability of Semax in human studies (no major adverse effects)Reference

Side Effects & Safety

Long-Term Safety Data

• Limited long-term human data on N-Acetyl Selank specifically; safety extrapolated from Selank clinical use

🧮 Dose Calculator

Concentration
33.3
mcg/unit
Draw Volume
15
units (0.150 mL)
For a 500 mcg dose, draw 15 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
Low CNS penetration; not typically used
Oral Administration
Poor due to enzymatic degradation
Intranasal
High CNS bioavailability; intranasal route bypasses blood-brain barrier via olfactory nerves
Half-Life
Likely short (5–15 minutes in plasma); longer CNS effects due to gene expression changes
Degradation
Cleared by tissue peptidases
Tissue Specificity
CNS regions regulating anxiety, stress, and learning (amygdala, hippocampus, cortex)
⚗️

Peptide Details

Molecular Weight
751.89
Formula
C33H57N11O9
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
⚖️

Legal Status & Regulatory

RegionStatus
EUNot Approved
FDANot Approved
CanadaNot Approved
AustraliaNot Approved

Storage Instructions

Lyophilized (Powder)
freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 1–2 weeks; avoid freeze–thaw cycles
Reconstituted (Mixed)
Refrigerate at 2–8 °C (35.6–46.4 °F); use within 1–2 weeks for optimal potency