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← ConditionsWomen's hormonal & reproductive

Perimenopause / menopause

Two evidence-backed peptide lanes (metabolic, libido); HRT owns vasomotor/bone/sleep.

Decision support, not prescription. You decide.

Primary: Metabolic & Weight ManagementSecondary: Cognitive, Mood & NeuroSecondary: Sexual & Reproductive HealthSecondary: Sleep & CircadianSummary grade: strong
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Monitor — GLP-1 alters oral progesterone absorption

Delayed gastric emptying changes oral progesterone (and other oral drug) absorption/timing — adjust co-prescribing.

Candidate agents

3 agents · ranked by role, then evidence
PT-141 (Bremelanotide)peptide · headlineLeadFDA-approved
Evidence · PubMed
Strong

Bremelanotide FDA-approved for HSDD (premenopausal RCTs); postmenopausal off-label.

PMID 31599840
Community · Reddit
No community reports
Peers · your network
No peer data yet
Semaglutidepeptide · headlineLeadResearch use only

Monitor — GLP-1 alters oral progesterone absorption

Evidence · PubMed
Strong

GLP-1 addresses menopausal visceral-fat shift HRT does not; greater loss with HT.

PMID 38446869
Community · Reddit
No community reports
Peers · your network
No peer data yet
Tirzepatidepeptide · headlineResearch use only

Monitor — GLP-1 alters oral progesterone absorption

Evidence · PubMed
No evidence rows
Community · Reddit
Positive

6 reports · Peri weight gain + joint pain/inflammation resolved where HRT and PT failed

Peers · your network
No peer data yet

Matching protocol templates

Browse all →
Exenatide + Semaglutide Transition Strategy

Staggered hunger control, cost reduction, side effect modulation

6–12 weeks·2 components
Kisspeptin-10 + PT-141 + Cialis Libido Optimization Stack

Libido enhancement and erectile support

4–6 weeks (on demand)·3 components
PT-141 + Cialis Libido & Arousal Stack

Enhance sexual desire and response in men or women

1–2x per week as needed·2 components

The platform surfaces evidence, community signal and peer outcomes with enforced cautions. It never decides treatment — the licensed clinician orders labs, writes notes, and prescribes.