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PEG MGF
Growth Factors & Muscle BuildingPEG MGF is a PEGylated variant of Mechano Growth Factor, a splice form of IGF-1 expressed in muscle post-exercise. PEGylation significantly prolongs its half-life, making it more effective for sustained muscle repair and hypertrophy. It has been studied for its role in muscle recovery and hypertrophy in rodent models.
Reconstitute
2 mL BAC + 2mg vial
10 mcg/unit
Daily Range
100–400 mcg Subcutaneous (SQ)
2-3 times a week
Standard Dose
200 mcg
Cycle
4–8 weeks
then reassess
PEG MGFpegylationmuscle regenerationIGF-1 variantpost-workout recovery
Dosing & Reconstitution Guide
In animal models, PEG-MGF has been administered in the range of 200–400 μg per injection, 2–3x weekly. These values reflect rodent studies and do not apply to human dosing.
Standard / Gradual Approach
standardPhaseDoseVolume
Week 150mcg
Week 2100mcg
Week 3150mcg
Week 4200mcg
Protocol Summary
Subcutaneous (SQ): 2-3 times a week · Dose range 100–400 mcg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
SubQ Injection
Administer 2–3x per week, post-exercise. Typical cycle duration is 6–12 weeks followed by an equal off-cycle to avoid receptor fatigue or resistance.
🧪 Quick Start
BAC Water
2 mL
Potential Benefits & Use Cases
PEG-MGF is not approved for human use and should only be handled in research environments.
Investigated for promoting satellite cell activation
Studied for post-exercise muscle regeneration in animal models
Pegylation allows for prolonged systemic activity compared to native MGF
Explored in muscle atrophy and recovery models
May influence localized hypertrophy following muscle trauma (in rodents)
Clinical data Strong preclinical Limited data
Mechanism of Action
→PEGylation extends duration of action by reducing renal clearance
→Stimulates muscle satellite cells to promote regeneration
→Mimics localized IGF-1 splicing in response to mechanical loading
Lifestyle & Optimization
timing
Inject immediately following intense resistance training. Protein-carb meal within 30 minutes post-workout.
diet
High protein intake for muscle recovery.
exercise
Heavy compound lifts 4–5 times weekly.
sleep
Prioritize 8+ hours sleep for recovery.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Side Effects & Safety
Common Side Effects
• Localized irritation or swelling at injection site
Contraindications & Warnings
• Risk of immune sensitization with repeated long-term use
• Should not be used in individuals with active malignancies
Long-Term Safety Data
• Limited long-term safety data in humans
🧮 Dose Calculator
Concentration
10.0
mcg/unit
Draw Volume
50
units (0.500 mL)
For a 500 mcg dose, draw 50 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
High; PEG modification allows for sustained release and improved absorption
Oral Administration
Poor; rapidly degraded in the digestive tract
Half-Life
2–3 days with PEGylation
Degradation
Resists enzymatic breakdown due to PEG coating
Tissue Specificity
Targets skeletal muscle tissue and repair sites
⚗️
Peptide Details
Molecular Weight
2867.36
Formula
C121H200N42O39
Sequence
PEGylated IGF-1 Ec variant
⚖️
Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at 2-8°C
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 7-10 days post-reconstitution. PEG MGF has shorter stability; minimize storage duration and protect from repeated freeze-thaw.