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PAL-GHK
Anti-Aging & Skin HealthPAL-GHK is a lipopeptide derivative of the GHK sequence used in skin rejuvenation. It improves collagen synthesis, reduces signs of aging, and promotes epidermal repair. PAL-GHK is commonly found in cosmetic serums and creams for daily use to restore youthful skin structure and reduce inflammation.
Reconstitute
2 mL BAC + 10mg vial
50 mcg/unit
Daily Range
0.5–2 % Topical
Once or twice daily
Standard Dose
1 %
Cycle
4–8 weeks
then reassess
PAL-GHKlipopeptidecollagen synthesiscosmetic peptideanti-aging
Dosing & Reconstitution Guide
Commonly used in commercial cosmetic products at 2–5% concentration. It is not approved for injection or therapeutic use.
Standard / Gradual Approach
10mg VialstandardPhaseDoseVolume
Week 1100mcg
Week 2150mcg
Week 3200mcg
Week 4250mcg
Protocol Summary
Topical: Once or twice daily · Dose range 0.5–2 % with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending
Frequency & Cycling
Topical
Apply once or twice daily. Continuous use for 8–12 weeks recommended for optimal cosmetic benefit. Maintenance use can follow at 1x daily.
🧪 Quick Start
Vial Size
10 mg
BAC Water
2 mL
Concentration
5000 mcg/unit
Potential Benefits & Use Cases
PAL-GHK is a cosmetic research peptide, not approved for injectable or therapeutic use.
Enhances skin firmness and elasticity in cosmetic models
Stimulates collagen, elastin, and glycosaminoglycan synthesis
Used in anti-aging skincare products for wrinkle reduction
Lipidation improves skin absorption and bioavailability
Non-toxic and well-tolerated in topical application studies
Clinical data Strong preclinical Limited data
Mechanism of Action
→Enhances extracellular matrix (ECM) activity by stimulating fibroblasts
→Upregulates genes associated with skin regeneration and repair
→Suppresses pro-inflammatory cytokines and oxidative enzymes
→Promotes angiogenesis and glycosaminoglycan (GAG) synthesis
Lifestyle & Optimization
timing
Topical daily application or consistent SubQ schedule.
diet
Adequate water intake (2–3 liters daily). Include collagen-rich foods.
exercise
Moderate activity as tolerated.
sleep
Sleep 7–9 hours nightly for tissue repair. Protect skin from excessive sun exposure.
Peptide Research & Preclinical Studies
Evidence-Based Research Findings
Side Effects & Safety
Common Side Effects
• Mild irritation or redness at application site
• Temporary dryness or tingling
Contraindications & Warnings
• Patch test recommended before use in individuals with sensitive skin or rosacea
Long-Term Safety Data
• Well tolerated in long-term cosmetic use; no systemic adverse effects reported
🧮 Dose Calculator
Concentration
50.0
mcg/unit
Draw Volume
10
units (0.100 mL)
For a 500 mcg dose, draw 10 units on a U-100 insulin syringe
🧬
Bioavailability & Absorption
SubQ Injection
Rarely used; not formulated for injection
Oral Administration
Not viable orally; no clinical bioavailability via GI tract
Half-Life
Not clearly defined in topical use
Degradation
Metabolized locally by skin enzymes
Tissue Specificity
Targets dermis and epidermis for skin regeneration and anti-aging
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Peptide Details
Molecular Weight
578
Formula
C30H54N6O9
Sequence
Palmitoyl-Gly-His-Lys
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Legal Status & Regulatory
RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved
Storage Instructions
Lyophilized (Powder)
Store lyophilized powder at -20°C for long-term storage, or at 2-8°C for short-term
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 30 days. Protect from light exposure.