Back to Peptides

Mazdutide

Metabolic & Weight Loss

Mazdutide is a dual GLP-1 and glucagon receptor agonist developed for obesity and metabolic disorders. It improves glucose metabolism, increases satiety, reduces food intake, and promotes significant weight loss. Clinical studies have shown strong efficacy in reducing body weight and visceral fat, with ongoing trials exploring long-term cardiovascular and endocrine benefits. Developed by Innovent Biologics, it has shown promising results in early clinical trials in China

Reconstitute
2 mL BAC + 3mg vial
15 mcg/unit
Daily Range
2–9 mg Subcutaneous (SQ)
Weekly
Standard Dose
6 mg
Cycle
4–8 weeks
then reassess
GLP-1glucagondual agonistobesityweight lossMazdutide

Dosing & Reconstitution Guide

Clinical trials report weekly subcutaneous dosing between 1–10 mg. These protocols are investigational and not approved outside of formal studies.

Standard / Gradual Approach

standard
PhaseDoseVolume
Week 10.5mg
Week 51mg
Week 91.5mg
Week 132.5mg

Protocol Summary

Subcutaneous (SQ): Weekly · Dose range 2–9 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

SubQ Injection

Weekly injection; titration phase from 4 mg to 6–9 mg based on tolerance. Continuous use protocol under clinical supervision. Monitor glucose, lipids, renal function, and thyroid markers periodically.

🧪 Quick Start

Potential Benefits & Use Cases

Mazdutide is not FDA-approved and should only be used in clinical research environments.
Achieves 6–14% body weight reduction over 24–48 weeks in Phase 3 obesity trials (Phase 3)
Superior to semaglutide — 48% achieved HbA1c <7% plus ≥10% weight loss vs 21% semaglutide (Phase 3)
Reduces HbA1c by ~2.0% in type 2 diabetes at higher doses (Phase 3)
Favorable metabolic effects including improved lipid profiles (Phase 3)
Convenient once-weekly dosing improves adherence (Phase 3)
Clinical data Strong preclinical Limited data

Mechanism of Action

→GLP-1 receptor agonism
→Glucagon receptor agonism
→Enhances insulin secretion in a glucose-dependent manner
→Suppresses postprandial glucagon secretion
→Delays gastric emptying and promotes satiety

Lifestyle & Optimization

timing

Weekly injection. Consistent timing each week.

diet

Consistent meal schedule focusing on protein and vegetables. Monitor appetite and caloric intake — significantly reduces hunger.

exercise

Exercise 4–5 times weekly.

sleep

Stay well-hydrated (2–3 liters daily).

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
NEJM — Mazdutide for obesity: GLORY-2 phase 3 trialReference
The Lancet — Mazdutide in Chinese adults with type 2 diabetesReference
PubMed — Phase 1b/2a study of mazdutide in type 2 diabetesReference
Nature — GLP-1/glucagon dual agonism overviewReference
ClinicalTrials.gov — NCT05380947: GLORY-2 Phase 3 trialReference

Side Effects & Safety

Common Side Effects

• GI effects (nausea, vomiting, diarrhea, constipation) — typically mild-moderate, diminishing over time
• Gradual dose titration significantly improves tolerability

🧮 Dose Calculator

Concentration
15.0
mcg/unit
Draw Volume
33
units (0.330 mL)
For a 500 mcg dose, draw 33 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
High bioavailability when administered subcutaneously.
Oral Administration
Not currently available in oral form; absorption limited by enzymatic degradation.
Half-Life
Approximately 8–12 hours; supports once-weekly use
Degradation
Metabolized primarily via proteolysis and renal excretion
Tissue Specificity
Targets GLP-1 and glucagon receptors in brain, liver, pancreas, and adipose tissue
⚗️

Peptide Details

Molecular Weight
4679.44
Formula
C209H344N55O67
Sequence
H-His-Asp-Tyr-Tyr-Ser-Tyr-Gly-Leu-His-Gln-Lys-Thr-Lys-Pro-Arg-Tyr-NH2
⚖️

Legal Status & Regulatory

RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved

Storage Instructions

Lyophilized (Powder)
Store pre-filled pens at 2-8°C before first use. After first use, may store at room temperature (15-30°C) for up to 30 days. Never freeze. Protect from light.
Reconstituted (Mixed)
Refrigerate at 2–8°C after reconstitution. Use within 28 days.