Back to Peptides

AOD-9604

Metabolic & Weight Loss

AOD-9604 is a modified peptide fragment of human growth hormone designed to stimulate fat metabolism while avoiding the adverse effects associated with hGH therapy. It promotes lipolysis, inhibits fat formation, and has a proven safety profile in human studies. It has been explored in clinical research for obesity and metabolic modulation.

Reconstitute
null mL BAC + 2mg vial
Daily Range
400–600 mcg Subcutaneous (SQ)
Once daily
Standard Dose
500 mcg
Cycle
4–8 weeks
then reassess
AOD-9604fat loss peptidelipolysisgrowth hormone fragmentmetabolic health

Dosing & Reconstitution Guide

Doses in clinical trials ranged from 250–1000 μg daily. AOD-9604 is not approved for weight loss or therapeutic use outside of regulated trials.

Standard / Gradual Approach

2mg Vialstandard
PhaseDoseVolume
Week 1300mcg
Week 2300mcg
Week 3600mcg
Week 4600mcg

Protocol Summary

Subcutaneous (SQ): Once daily · Dose range 400–600 mcg with gradual titration
Oral: Once daily · Dose range 0.5–1.5 mg with gradual titration
Cycle Length: 4–8 weeks typical; reassess before extending

Frequency & Cycling

SubQ Injection

Inject 500 mcg in the morning while fasted. Cycle 20 days on, 10 days off, or up to 12 weeks with 2-week break. Effects build gradually; consistent use required for best outcomes.

🧪 Quick Start

Vial Size
2 mg
BAC Water
3 mL
Concentration
667 mcg/unit

Potential Benefits & Use Cases

AOD-9604 is not FDA-approved for fat loss or medical application. Research use only.
Achieves ~2.6 kg weight loss over 12 weeks at 1 mg/day vs 0.8 kg placebo in early trials (human trial)
Preferential loss of abdominal fat, resembling low-dose hGH pattern (human trial)
Does not raise IGF-1 levels; shows placebo-like safety profile with no antibody formation (human trial)
Preliminary preclinical data suggests cartilage repair and bone health potential (preclinical)
Clinical data Strong preclinical Limited data

Mechanism of Action

→Stimulates lipolysis
→Inhibits lipogenesis
→Mimics metabolic region of hGH without affecting IGF-1 levels

Lifestyle & Optimization

timing

Inject on empty stomach, preferably before exercise.

diet

Maintain a slight caloric deficit (300–500 calories below maintenance).

exercise

Consistent resistance training and moderate cardio 4–5 times per week.

sleep

Prioritize 7–9 hours of sleep. Stay well-hydrated.

Peptide Research & Preclinical Studies

Evidence-Based Research Findings

Study TitleType
Journal of Endocrinology and Metabolism (2014) — Safety and metabolismReference
Journal of Endocrinology and Metabolism (2013) — Safety profileReference
FDA Advisory Committee (2024) — Regulatory overviewReference
Endocrinology (OUP) — Effects on lipid metabolismReference
Gastroenterology — Drug treatment of overweightReference
Annals of Clinical and Laboratory Science — Intra-articular AOD9604Reference
DrugBank — AOD9604 summaryReference

Side Effects & Safety

Long-Term Safety Data

• Development terminated in 2007 — larger Phase IIb trial (536 subjects, 24 weeks) failed to achieve statistical significance; drug not FDA-approved

🧮 Dose Calculator

Concentration
10.0
mcg/unit
Draw Volume
50
units (0.500 mL)
For a 500 mcg dose, draw 50 units on a U-100 insulin syringe
🧬

Bioavailability & Absorption

SubQ Injection
High bioavailability with expected systemic absorption.
Oral Administration
Clinically relevant absorption reported for troche/sublingual forms; enhanced with mucosal delivery.
Half-Life
Approximately 4 hours
Degradation
Metabolized by proteolytic enzymes in peripheral tissue
Tissue Specificity
Primarily targets adipose tissue; also shows chondrocyte activation in cartilage
⚗️

Peptide Details

Molecular Weight
1813.1
Formula
C112H179N29O35S
Sequence
Tyr-hGH177-191
⚖️

Legal Status & Regulatory

RegionStatus
FDANot Approved
EUNot Approved
AustraliaNot Approved
CanadaNot Approved

Storage Instructions

Lyophilized (Powder)
Store lyophilized powder at 2-8°C or below
Reconstituted (Mixed)
After reconstitution, maintain at 2-8°C and use within 30 days. Protect from light and keep in original vial.