Adrenal / cortisol dysregulation
Dysregulated HPA output; normalize the adrenal axis.
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Candidate agents
6 agents · ranked by role, then evidenceSynthetic ACTH directly stimulates adrenal cortisol output and is the standard dynamic test of adrenal reserve; a subnormal cortisol rise confirms adrenal insufficiency.
PMID 40049331Vasopressin acts on pituitary corticotroph V1b receptors to potentiate CRH and drive ACTH/cortisol; excessive V1b activation underlies HPA hyperactivity that V1b blockade can normalize.
PMID 26762848In humans, higher oxytocin levels accompany a more moderated HPA (ACTH/cortisol) response to acute psychosocial stress, consistent with an inhibitory role on adrenal-axis output.
PMID 22856618PACAP controls HPA-axis activation, driving CRH expression in the paraventricular nucleus and adrenocortical steroidogenic gene expression to sustain corticosterone secretion during stress.
PMID 21824204Plasma DSIP-like immunoreactivity correlates with pre-dexamethasone cortisol and is altered by dexamethasone suppression, indicating DSIP is involved in glucocorticoid/HPA-axis regulation.
PMID 9606527Spironolactone is the preferred mineralocorticoid-receptor antagonist for medical management of primary aldosteronism, controlling aldosterone-driven hypertension and hypokalemia better than eplerenone.
PMID 40658500Matching protocol templates
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