N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is a nootropic peptide derived from tuftsin and enhanced through N-acetylation for improved stability. It modulates GABA, serotonin, and neurotrophic signaling and has demonstrated powerful anti-anxiety, cognitive-enhancing, and immunomodulatory effects in preclinical and clinical settings. Its intranasal use enables fast CNS action with a high safety margin. It has been investigated in Russian research for immune modulation and neurochemical balance.

• Modulates GABAergic neurotransmission via gene expression and receptor sensitivity
• Influences serotonin and dopamine balance through neuropeptide regulation
• Upregulates BDNF expression and neuroplasticity markers
• Reduces pro-inflammatory cytokines in brain and periphery
• Enhances adaptive stress response and immune homeostasis

• unit: mcg

  low dose: 200

  frequency: 1–3x daily

  high dose: 500

  standard dose: 300

  administration route: Intranasal

• Use 1–3x per day for 10–14 days. Repeat cycles monthly as needed for mood, anxiety, or performance support.

long term: ["Limited long-term human data on N-Acetyl Selank specifically; safety extrapolated from Selank clinical use"]

sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

half life: Likely short (5–15 minutes in plasma); longer CNS effects due to gene expression changes

degradation: Cleared by tissue peptidases

molecular weight: 751.89

molecular formula: C33H57N11O9

tissue specificity: CNS regions regulating anxiety, stress, and learning (amygdala, hippocampus, cortex)

• Functional Connectomic Approach to Studying Selank and Semax Effects.clinicalPMID 32342318 ↗
• Selank Attenuates Aversive Signs of Morphine Withdrawal in Rats.preclinicalPMID 36322304 ↗
• Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety.preclinicalPMID 28280289 ↗