NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme involved in redox reactions, DNA repair, and energy metabolism. NAD+ precursors and NAD+ IV/IM formulations are studied for their effects on aging, mitochondrial health, and cellular stress.

• Serves as a coenzyme in redox reactions facilitating ATP production
• Acts as a substrate for sirtuins and PARPs
• Regulates circadian rhythms and immune responses
• Maintains NAD+/NADH and NADP+/NADPH redox balance
• Activates PGC-1α through SIRT1, promoting mitochondrial biogenesis
• Supports antioxidant response via FOXO and NRF2 activation

• unit: mg

  low dose: 250

  frequency: daily

  high dose: 1000

  standard dose: 500

  administration route: Oral

• unit: mg

  low dose: 250

  frequency: once weekly

  high dose: 1000

  standard dose: 500

  administration route: Intravenous (IV)

• unit: mg

  low dose: 25

  frequency: 1-3 times per week

  high dose: 100

  standard dose: 50

  administration route: Subcutaneous (SQ)

• 25 mg - 100 mg 1–3 times per week as per Dr. Jatoi protocol

common: ["Insomnia, anxiety, or fatigue if escalated too quickly; gradual titration advised","Transient headache or flushing (dose-dependent)","Doses exceeding 200–300 mg/day reserved for supervised use"]

half life: 1-2 hours

degradation: Metabolized by conversion to NADH as part of the cellular redox reactions

molecular weight: 663.43

molecular formula: C21H27N7O14P2

tissue specificity: Mitochondria

• NAD+ in aging, metabolism, and neurodegeneration.reviewPMID 26785480 ↗
• NAD+ and sirtuins in aging and disease.reviewPMID 24786309 ↗