MOTS-c

MOTS-c is a mitochondrial-derived peptide with potential therapeutic applications in metabolic and age-related diseases. It is involved in metabolic regulation, showing promise in conditions like insulin resistance and obesity. It has been evaluated in rodent models and cell culture for potential applications in aging and metabolic disorders.

• Regulates nuclear gene expression, promoting cellular homeostasis.
• Activates AMPK pathway, enhancing glucose uptake and fatty acid oxidation.
• Translocates to the nucleus during metabolic stress, influencing gene expression.
• Inhibits folate-dependent de novo purine biosynthesis, increasing AICAR levels to activate AMPK.
• Upregulates mitochondrial biogenesis via PGC-1α, NRF-1/2, and TFAM.
• Enhances thermogenesis through UCP1 and cAMP-mediated pathways.

• unit: mg

  low dose: 5

  frequency: 3 times per week

  high dose: 15

  standard dose: 10

  administration route: Subcutaneous (SQ)

• Standard Protocol: 10 mg subQ injection, 3 times per week. Alternative Protocol: 5 mg daily subQ injections for 4 weeks, then reassess.

common: ["Fatigue/lethargy during adjustment period (user-reported)","Appetite fluctuation, nausea/bloating, headache, flushing (user-reported)"]

warnings: ["Increased heart rate/palpitations, insomnia at higher doses (user-reported)","Research-grade purity often only 60%, confounding reports (sourcing concern)"]

sequence: MRWQEMGYIFYPRKLR

half life: Estimated short half-life (2–4 hours); rapidly cleared.

degradation: Metabolized within cellular environments, subject to enzymatic degradation.

molecular weight: 1951.2

molecular formula: C85H136N20O20S2

tissue specificity: Affects skeletal muscle and metabolically active tissues; regulates glucose and mitochondrial homeostasis.

• The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity.mechanismPMID 25738459 ↗
• MOTS-c Translocates to the Nucleus to Regulate Gene Expression in Response to Metabolic Stress.mechanismPMID 29983246 ↗
• MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.reviewPMID 36761202 ↗