Estradiol

hormone · comparatorFDA-approved

Estrogen receptor agonism

Summary

Estrogen replacement — the backbone of menopausal HRT. Transdermal preferred (lower VTE risk).

How it works

Estrogen receptor agonism

Dosing

unit: mg/day
frequency: patch 1–2x weekly
standard dose: 0.05
administration route: Transdermal

Cycling

Continuous

Side effects

common: ["Breast tenderness","Bloating","Unscheduled bleeding"]

warnings: ["VTE risk (oral > transdermal); needs progesterone if uterus intact"]

Verified citations

2 · PubMed-checked

Tailoring transdermal estradiol dose to maximize benefits and minimize risks.reviewPMID 41529140 ↗
Menopausal Hormone Therapy and Cardiovascular Disease: Role of Formulation, Dose, and Route.reviewPMID 33506261 ↗

Used for

Legal / compounding

FDA-approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.