N-Acetyl Epithalon Amidate

N-Acetyl Epithalon Amidate is a bioavailable synthetic peptide analog of Epitalon designed to support DNA repair, telomere lengthening, and pineal regulation. It may improve sleep, boost cognitive performance, and delay signs of biological aging through epigenetic and circadian mechanisms in animal models.

• Upregulates telomerase gene (TERT) expression and telomere stabilization
• Modulates circadian rhythm gene clusters via pineal axis signaling
• Regulates chromatin and epigenetic transcription pathways
• Activates protein synthesis during neurogenesis and tissue repair

• unit: mcg

  low dose: 100

  frequency: Daily

  high dose: 1000

  standard dose: 300

  administration route: Subcutaneous (SQ)

• Cycle: 8–10 weeks daily, followed by 2–4 month break. Protocol may repeat 1–2x annually.

common: ["Transient sleep pattern changes may occur"]

sequence: N-acetyl-Ala-Glu-Asp-Gly-amidate

half life: 4 hours

degradation: Metabolized by peptidases and cleared via renal excretion

molecular weight: 519.69

molecular formula: C28H45N5O4

tissue specificity: Pineal gland, hippocampus, retina, and hypothalamus

• Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide.reviewPMID 40141333 ↗
• Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.mechanismPMID 12937682 ↗
• Epithalon decelerates aging and suppresses breast adenocarcinomas in transgenic her-2/neu mice.preclinicalPMID 12459848 ↗