🏥 Hormone Regulation & Endocrine Support
8 peptides in this category
Seractide/ACTH (1-39)
ACTH (1-39), also known as Seractide, is a full-length synthetic form of adrenocorticotropic hormone used to evaluate adrenal function in diagnostic testing. It mimics natural ACTH, triggering cortisol release from the adrenal cortex in response to hypothalamic or pituitary dysfunction.
0.25 mg IM or IV as a single dose for adrenal stimulation testing. Monitor cortisol response within 30–60 minutes.
Cetrorelix
Cetrorelix is a synthetic GnRH antagonist used to suppress LH and FSH secretion during controlled ovarian stimulation in IVF. It enables precise timing of ovulation and prevents premature hormonal surges that can compromise reproductive outcomes.
Daily protocol: 0.25 mg SQ once daily starting day 5–6 of ovarian stimulation for 5–10 days. Single-dose protocol: 3 mg SQ once on stimulation day 7 (lasts ~4 days, no daily injections needed). Both protocols used in ART under strict monitoring.
Gonadorelin
Gonadorelin is a synthetic gonadotropin-releasing hormone (GnRH) used for diagnostic and therapeutic purposes in reproductive and endocrine medicine. It stimulates the anterior pituitary to release LH and FSH and is used in fertility restoration, hormone replacement, and hypothalamic amenorrhea treatment.
Standard diagnostic dose: 0.1 mg IV as a single bolus. Therapeutic pulsatile use: 5–20 mcg IV or SubQ every 90–120 minutes for HRT or fertility.
Kisspeptin-10
Kisspeptin-10 is a potent regulator of reproductive hormone signaling that stimulates GnRH secretion from the hypothalamus, which in turn increases LH and FSH levels to support testosterone, estrogen, and fertility. It has been studied for its role in treating hypogonadism, improving libido, and optimizing reproductive cycles. Emerging research also suggests metabolic benefits through its effects on insulin sensitivity and fat regulation.
Clinical research doses: 1–10 mcg/kg IV or SQ as single bolus. Diagnostic use: 1 mcg/kg IV to assess gonadotropin response. Therapeutic research: 4–10 mcg/kg SQ daily for 2–4 weeks in reproductive endocrine studies. Monitor LH, FSH, testosterone, and estrogen.
Melanotan II
Melanotan II is a synthetic melanocortin peptide that increases melanin production and stimulates sexual arousal. It binds MC1R for tanning and MC4R for libido enhancement, and has been studied for its effects on skin pigmentation and sexual arousal in preclinical models and limited human trials. Unlike MT-1, it has central nervous system activity.
0.5 mg SubQ as needed. Titrate up from 0.25 mg to assess sensitivity. Cycle 10–14 days for tanning, then reduce to 1–2x/week.
Melanotan I
Melanotan I (afamelanotide) is a synthetic alpha-MSH analog used to increase melanin production and reduce UV sensitivity. Approved for photoprotection in EPP, it provides a cosmetic tanning effect and may offer broader applications for sunburn prevention and skin tone enhancement.
0.5 mg SubQ daily for 10–14 days. Maintenance: 1–2x per week thereafter.
PT-141 (Bremelanotide)
PT-141 (Bremelanotide) is a melanocortin receptor agonist used for sexual enhancement. Unlike PDE5 inhibitors, it works in the brain to increase arousal and libido. It is FDA-approved for female sexual dysfunction and used off-label in men to improve sexual function without affecting vascular systems.
FDA-approved dose (Vyleesi): 1.75 mg SQ ~45 minutes before sexual activity. Max 1 dose per 24 hours, max 8 doses per month. Start at 0.75 mg to assess tolerance. Approved for premenopausal women with HSDD; off-label use in men for erectile dysfunction.
HCG (Human Chorionic Gonadotropin)
Human Chorionic Gonadotropin (HCG) is a peptide hormone that mimics luteinizing hormone (LH), stimulating testosterone production from Leydig cells and supporting spermatogenesis. Used clinically for male fertility preservation, testosterone support during replacement therapy, and post-cycle therapy recovery.
Standard dose: 250-500 IU every other day (3x weekly) SubQ for TRT support; 1500-5000 IU 2-3x weekly for PCT.