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Thymalin

peptide · headline503A compounded

Modulates immune cell activity by enhancing T-cell differentiation and thymic function

Summary

Thymalin is a thymic peptide complex known for its potent immunoregulatory effects, supporting T-cell maturation, reducing inflammation, and improving thymic function. It has been investigated for anti-aging, immune optimization, and cancer adjunctive support.

How it works

  • Modulates immune cell activity by enhancing T-cell differentiation and thymic function
  • Reduces systemic inflammation by suppressing pro-inflammatory cytokines
  • Supports thymus gland function, crucial for maintaining immune homeostasis during aging
  • Zinc-dependent activity: Thymulin requires sufficient zinc levels for optimal biological activity

Dosing

  • unit: mg
    low dose: 5
    frequency: daily
    high dose: 20
    standard dose: 10
    administration route: Subcutaneous (SQ)

Cycling

  • Initial loading: 10 mg daily for 5–10 days. Maintenance: 1–2x weekly for 6–12 weeks. Repeat up to 3 cycles annually for immune support and thymic rejuvenation.

Side effects

common: ["Localized pain at injection site"]
warnings: ["Use under medical supervision in patients with serious immune disorders"]
long term: ["No known long-term issues with clinical use"]

Chemistry & PK

sequence: Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
half life: Less than 30 minutes
degradation: Predominantly by blood proteases
molecular weight: 857
molecular formula: C33H54N12O15
tissue specificity: Targets thymus and immune-related tissues

Verified citations

3 · PubMed-checked
  • Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.mechanismPMID 33237528
  • Peptides of pineal gland and thymus prolong human life.clinicalPMID 14523363
  • The Influence of KE and EW Dipeptides in Thymalin on Gene Expression in COVID-19.mechanismPMID 37686182

Used for

No condition evidence rows yet.

Legal / compounding

503A compounded

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.