TB-500

TB-500 is a synthetic peptide modeled after Thymosin Beta-4 that promotes tissue regeneration, reduces inflammation, and supports recovery in musculoskeletal injuries. It is often used by researchers and clinicians for its potent actin-binding properties and ability to enhance healing in muscles, tendons, ligaments, and even cardiac tissue.

• Promotes cell migration
• Enhances collagen deposition
• Reduces inflammation
• Upregulates actin-binding proteins to enhance cytoskeletal repair
• Improves angiogenesis and tissue oxygenation
• Supports endothelial integrity and cardiac repair

• unit: mg

  low dose: 2

  frequency: every other day (loading); weekly (maintenance)

  high dose: 3

  standard dose: 2.5

  administration route: Subcutaneous (SQ)

• Loading Phase: 2.5 mg subQ injection every other day for 4–6 weeks. Maintenance Phase: 2 mg subQ injection once weekly.

common: ["Headaches, especially first few days","Slight energy drop early in treatment"]

warnings: ["Possible BP decreases, dizziness, palpitations at higher doses","Anaphylaxis risk in hypersensitive individuals"]

sequence: Ac-Ser-Asp-Lys-Pro-Thr-Phe-Ser-Pro-Lys-Glu-Lys-Lys-Cys-Asp-Glu-Leu-Ser-Kys-Leu-Tyr-Glu-Asp-Gly-Asp-Tyr-Phe-Ser-Asp-Cys-Phe-Leu-Cys-His-Val

half life: 1–2 days

degradation: Metabolized primarily in the liver.

molecular weight: 4963.49

molecular formula: C212H350N56O78S

tissue specificity: Affects muscle, connective tissues, and tendons.

• Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.reviewPMID 41490200 ↗
• Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.reviewPMID 41476424 ↗