Tadalafil

on-label Rx · comparatorFDA-approved

PDE5 inhibition → vasodilation

Overview

PDE5 inhibitor for erectile/vascular function; pairs with PT-141 (central + vascular arousal). Also used low-dose daily for vascular healthspan.

How it works

PDE5 inhibition → ↑ cGMP → vasodilation

Dosing

Daily 2.5–5 mg, or PRN 10–20 mg.

Oral5 mg standardrange —–20 mg· daily or PRN

Cycling

Continuous or on-demand

Side effects

Common: Headache
Flushing
Nasal congestion
Warnings: Contraindicated with nitrates

Verified citations

2 · PubMed-checked

Direct comparison of tadalafil with sildenafil for erectile dysfunction: meta-analysis.clinicalPMID 28741090 ↗
Tadalafil in the treatment of erectile dysfunction.reviewPMID 14622501 ↗

Reconstitution

Not applicable — this compound is oral. No vial reconstitution needed.

Used for

Legal / compounding

FDA-approved

FDA: Approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.