Sermorelin

Sermorelin is a synthetic GHRH analog that stimulates the pituitary to release natural growth hormone, offering a safer and more physiologic alternative to direct GH therapy. Commonly used in adults with GH deficiency, it supports sleep, fat metabolism, recovery, and muscle tone.

• Stimulates release of growth hormone from the anterior pituitary
• Mimics the action of endogenous growth hormone-releasing hormone (GHRH)

• unit: mcg

  low dose: 1

  frequency: Daily

  high dose: 2

  standard dose: 1.5

  administration route: Subcutaneous (SQ)

• Inject daily at night to mimic natural GH rhythms. Suggested cycle is 8–12 weeks on followed by a 4-week break.

common: ["Injection-site reactions (~17% incidence in trials)","~6.5% developed subclinical hypothyroidism; untreated hypothyroidism blunts GH response"]

warnings: ["Rare systemic effects (<1%): headache, flushing, dizziness, hives"]

sequence: HAGGGYTDAIFNSYRK-VNRRG

half life: Approximately 12 minutes

degradation: Primarily metabolized by hepatic and renal peptidases

molecular weight: 3357.882

molecular formula: C149H246N44O42S

tissue specificity: Targets pituitary GHRH receptors to trigger GH secretion

• Sermorelin: a review of its use in the diagnosis and treatment of children with GH deficiency.reviewPMID 18031173 ↗
• Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum IGF-1 Levels.clinicalPMID 28830317 ↗