Micronized progesterone

hormone · comparatorFDA-approved

Progesterone receptor agonism; GABAergic sleep metabolite

Overview

Micronized progesterone — endometrial protection alongside estrogen, with a sedative benefit for sleep.

How it works

Progesterone receptor agonism
GABAergic metabolite (sleep)

Dosing

100–200 mg PO at bedtime.

Oral100 mg standardrange —–200 mg· QHS

Cycling

Continuous or cyclic

Side effects

Common: Sedation
Dizziness
Warnings: Note: GLP-1 delayed gastric emptying alters oral absorption/timing

Verified citations

2 · PubMed-checked

Diagnostic and therapeutic use of oral micronized progesterone in endocrinology.reviewPMID 38652231 ↗
Oral micronized progesterone for perimenopausal night sweats and hot flushes: Phase III RCT.clinicalPMID 37277418 ↗

Reconstitution

Not applicable — this compound is oral. No vial reconstitution needed.

Used for

Insomnia / circadianEmerging

Legal / compounding

FDA-approved

FDA: Approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.