Orexin A

Orexin A is a wake-promoting neuropeptide that modulates sleep, alertness, appetite, and cognitive function. It acts on orexin receptors in the brain and is being researched as a treatment for narcolepsy, fatigue, and age-related cognitive decline. Intranasal delivery allows fast CNS uptake for energizing and neurostimulant effects.

• Binds to orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R) in the brain
• Activates neurons in the hypothalamus, brainstem, and cortex
• Promotes sustained wakefulness by modulating dopamine, norepinephrine, histamine, and acetylcholine pathways
• Regulates energy homeostasis, feeding, and reward signaling

• unit: mg

  low dose: 1

  frequency: 1x daily in the morning or before demanding cognitive activity

  high dose: 5

  standard dose: 2.5

  administration route: Intranasal

• Use 1x daily in the morning or pre-task. Cycle 5 days on, 2 days off if used long-term to prevent desensitization.

common: ["Mild headache","Nasal dryness","Increased heart rate"]

warnings: ["Avoid use in individuals with severe cardiovascular disease or insomnia","May exacerbate anxiety or restlessness in sensitive users"]

long term: ["Limited long-term human data; use cautiously in chronic regimens"]

sequence: NH2-CDSPCSVGPGVVGPGVNGVGNGRKSGSKSQTQTQTQTQTQTQTQTQTV-COOH

half life: 15–30 minutes systemically; CNS effects last longer

degradation: Metabolized by peptidases in blood and brain

molecular weight: 3562.1

molecular formula: C146H246N44O42S1

tissue specificity: Targets orexin neurons in hypothalamus, cortex, and limbic regions

• The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.mechanismPMID 17299454 ↗
• Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.reviewPMID 31324898 ↗