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← Compounds

Levothyroxine

on-label Rx · comparatorFDA-approved

Thyroid hormone replacement (T4)

Summary

Synthetic T4 — the backbone of Hashimotos/hypothyroid management. Peptides are layered on top, never in place of it.

How it works

  • Thyroid hormone replacement (T4→T3)

Dosing

  • unit: mcg
    frequency: daily, fasting
    standard dose: 100
    administration route: Oral

Cycling

  • Continuous, lifelong

Side effects

common: ["(Over-replacement) palpitations, anxiety"]
warnings: ["Over-replacement → bone/cardiac risk"]

Verified citations

2 · PubMed-checked
  • Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Combination in Hypothyroidism.clinicalPMID 34185829 ↗
  • Treating hypothyroidism: subclinical hypothyroidism, TSH goals, alternatives to levothyroxine.reviewPMID 34766382 ↗

Used for

No condition evidence rows yet.

Legal / compounding

FDA-approved

Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.