Hexarelin

Hexarelin is a potent growth hormone secretagogue peptide that stimulates GH release via ghrelin receptor binding. It is studied in animal models and human research for its robust GH stimulation and potential cardiovascular effects. Although effective, long-term continuous use may lead to GH axis desensitization.

• Binds to ghrelin receptor (GHS-R1a)
• Stimulates release of growth hormone from the anterior pituitary
• Activates GH-dependent anabolic and lipolytic pathways

• unit: mcg

  low dose: 0.5

  frequency: Daily

  high dose: 2

  standard dose: 1

  administration route: Subcutaneous (SQ)

• unit: mcg

  low dose: 1

  frequency: Twice daily

  high dose: 3

  standard dose: 1.5

  administration route: Intramuscular (IM)

• Administer daily or 5 days on, 2 days off. Cycle for 8–12 weeks with equal time off to prevent desensitization.
• Inject 1–2x daily, especially post-workout. Limit cycle to 6–10 weeks followed by GH recovery phase.

common: ["Injection site irritation","Mild headache","Increased appetite"]

warnings: ["Potential increase in prolactin and cortisol at high doses","Monitor for GH desensitization during prolonged use"]

long term: ["May reduce endogenous GH response with long-term continuous use"]

sequence: H-Aib-His-D-2-Nal-Ala-Trp-D-Phe-2-Nal-Arg-Lys

half life: 0.5–1 hour

degradation: Primarily metabolized in the liver and kidneys.

molecular weight: 887.04

molecular formula: C47H58N12O6

tissue specificity: Affects pituitary, skeletal muscle, and adipose tissue.

• The GH Secretagogue Hexarelin Protects Rat Cardiomyocytes From Ischemia/Reperfusion Injury.preclinicalPMID 28321024 ↗
• The Safety and Efficacy of Growth Hormone Secretagogues.reviewPMID 28400207 ↗