GHRP-2

GHRP-2 is a potent growth hormone secretagogue that stimulates the natural release of GH via the ghrelin receptor. It has been evaluated in preclinical and limited human research for its endocrine and appetite-regulating effects. It supports GH-IGF-1 axis activation with minimal prolactin or cortisol impact at moderate doses.

• Binds to ghrelin receptor (GHS-R1a) on pituitary somatotrophs
• Promotes endogenous pulsatile GH secretion
• Enhances IGF-1 production downstream of GH
• Activates hunger and energy regulation via hypothalamic stimulation

• unit: mcg

  low dose: 100

  frequency: 1-2 times daily (pre-meal or pre-sleep)

  high dose: 300

  standard dose: 200

  administration route: Subcutaneous (SQ)

• Use 1–2x daily for 6–12 weeks, followed by 2–4 week break to reset receptor sensitivity. Combine with GH-releasing peptides like CJC-1295 for best results.

common: ["Transient appetite increase (ghrelin receptor activation)","Transient cortisol and prolactin elevation","Receptor desensitization (tachyphylaxis) with continuous daily use; cycling recommended"]

sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2

half life: Approx. 30 minutes

degradation: Metabolized hepatically and renally

molecular weight: 817

molecular formula: C45H55N9O6

tissue specificity: Targets pituitary gland and hypothalamus

• Pralmorelin: GHRP 2, growth hormone-releasing peptide 2.reviewPMID 15230633 ↗
• GHRP-2, like ghrelin, increases food intake in healthy men.clinicalPMID 15699539 ↗