Dihexa

Dihexa is a synthetic neurogenic peptide that enhances cognitive performance and brain plasticity through HGF/c-Met activation. It promotes memory formation, synaptic repair, and long-term potentiation, and is under investigation for Alzheimer's, stroke recovery, and neurodegeneration.

• Activates hepatocyte growth factor (HGF)/c-Met signaling to enhance neurogenesis
• Promotes synaptic connectivity and dendritic branching
• Elevates brain-derived neurotrophic factor (BDNF)
• Mimics angiotensin IV action in CNS

• unit: mg

  low dose: 2

  frequency: Once daily

  high dose: 10

  standard dose: 5

  administration route: Oral

• unit: %

  low dose: 0.5

  frequency: Apply 1–2x daily

  high dose: 2

  standard dose: 1

  administration route: Topical

• Use once daily for 8–12 weeks. Monitor for cognitive benefit and cycle off 2–4 weeks between blocks.
• Apply 1–2x daily to temples or back of neck for localized neurodermal delivery. Follow same cycle as oral use.

common: ["Headache","Mild nausea","Occasional restlessness or stimulation"]

warnings: ["Potential overstimulation of HGF/c-Met pathway could raise tumorigenic risk in predisposed individuals","Avoid use with active cancers"]

long term: ["Long-term safety in humans is unknown; preclinical trials suggest neurogenic persistence"]

sequence: Hexanoyl-Tyr-Ile-Ahx-NH2

half life: Not precisely defined; effects persist due to synaptic changes

degradation: Liver metabolism; avoids first-pass peptide degradation

molecular weight: 738.9

molecular formula: C39H62N8O6

tissue specificity: Central nervous system: cortex, hippocampus, limbic structures

• The Brain HGF/c-Met Receptor System: A New Target for Alzheimer's Disease.reviewPMID 25649658 ↗
• The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's.reviewPMID 25455861 ↗