← Compounds
Berberine
supplement · adjunctOTCAMPK activation
Summary
Plant alkaloid; AMPK activator with glycemic and lipid effects. Community "natural metformin."
How it works
- AMPK activation
- ↓ hepatic glucose output
Dosing
- unit: mgfrequency: 2–3x dailystandard dose: 500administration route: Oral
Cycling
- Continuous
Side effects
common: ["GI upset, cramping"]
warnings: ["CYP interactions"]
Verified citations
2 · PubMed-checked- Therapeutic effect of berberine on metabolic diseases: pharmacological and clinical evidence.reviewPMID 33186794 ↗
- Berberine Phospholipid Is an Effective Insulin Sensitizer in Women with PCOS.clinicalPMID 34684666 ↗
Used for
No condition evidence rows yet.
Legal / compounding
OTC
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.